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2 edition of mechanism of the gubernaculum testis found in the catalog.

mechanism of the gubernaculum testis

Cleland, John

mechanism of the gubernaculum testis

with an introductory sketch of the development of the testes, and an appendix on the purpose of their descent from the abdomen.

by Cleland, John

  • 226 Want to read
  • 4 Currently reading

Published by Maclachlan and Stewart in Edinburgh .
Written in English

    Subjects:
  • Testis.,
  • Epididymis.

  • Edition Notes

    StatementBy John Cleland, M.D. Prize thesis.
    Classifications
    LC ClassificationsQL878 .C6
    The Physical Object
    Pagination40 p.
    Number of Pages40
    ID Numbers
    Open LibraryOL6460216M
    LC Control Number43039327

    As the main receptors of estrogen, ER plays important role to mediate the biological effects of estrogens in gubernaculum testis because testis gubernaculum grew slowly, were atrophied, and even developed cryptorchid symptoms in Era knockout mice. In addition, Era and Erg mRNA and proteins have been detected in rat gubernaculum by: 5. Testicular torsion is a twisting of the spermatic cord and its contents and is a surgical emergency affecting per , males younger than 18 years annually. It accounts for 10% to 15% ofCited by:

    Cryptorchidism is the absence of one or both testes from the word is from the Greek κρυπτός, kryptos, meaning hidden, and ὄρχις, orchis, meaning is the most common birth defect of the male genital tract. About 3% of full-term and 30% of premature infant boys are born with at least one undescended lty: Medical genetics. Many theories have been proposed to explain the mechanism of testicular descent. The traction theory suggests that the testis is pulled into the scrotum by the by: 4.

    DES Info: DES effects on the testis Diethylstilbestrol Regulates the Expression of LGR8 in Mouse Gubernaculum Testis Cells Hormonal effects on the gubernaculum can affect testicular descent. In this chapter we summarise the main conclusions of this book. Testicular descent has evolved only in mammals and in modern mammals and humans it occurs in 2 separate steps, with different anatomy and hormonal control. The first step occurs when the developing testis produces insulin-like hormone 3 (INSL3) to make the gubernaculum : John M. Hutson, Jørgen M. Thorup, Spencer W. Beasley.


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Mechanism of the gubernaculum testis by Cleland, John Download PDF EPUB FB2

This is a reproduction of a book published before This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process.

We believe this work is culturally important, and despite the imperfections,Author: John Cleland. The Testicular Descent in Human: Origin, Development and Fate of the Gubernaculum Hunteri, Processus Vaginalis Peritonei, and Gonadal Ligaments (Advances Embryology and Cell Biology Book ) Softcover reprint of the original 1st ed.

Edition, Kindle EditionManufacturer: Springer. The proximal and distal attachments of the gubernaculum were severed in neonatal rats to examine their role in testicular descent and their relationship to transection of the genitofemoral nerve, which prevents descent of the testis.

In 34 of 82 animals proximal transection of the gubernaculum resulted in descent of the by: This book provides a state of the art overview of all aspects of testicular descent and cryptorchidism, including the mechanisms of descent and the causes, consequences, diagnosis, and treatment. The testicular descent (descensus testis) is described in a complete series of human material from stage 14 CC to the adult state by using own phases.

Central points of interest in this work are answers to questions which have been discussed controversially by generations of scientists and which. Cryptorchidism is the failure of the testis to descend into the scrotum, testicular descent is an complex process in testes development, and the gubernaculum plays an essential role in the complex.

Cleland J The mechanism of the gubernaculum testis, with an introductory sketch of the development of the testes, and an appendix on the purpose of their descent from the abdomen.

Edinburgh, Maclachan and Stewart. Google ScholarAuthor: Charalampos Mamoulakis. The enlarged gubernaculum holds the testis near the future inguinal canal as the embryo enlarges. By contrast, failure of the homologous structure in the female to enlarge allows the ovary to ascend with the kidney, as seen in rodents, or to remain near the enlarging uterus, as seen in : John M.

Hutson, Marilyn L. Baker, Masaru Terada, Baiyun Zhou, Georgia Paxton. In humans and other mammals, the developing testis is connected to the abdominal wall by the cranial suspensory ligament and the gubernaculum.

A peptide hormone called insulin-like 3 (INSL3) was found to be a master regulator of gonadal positioning in mammals by controlling gubernacular growth [ 1 ], but key questions by: 5. The Physiology of the Testis.

shrinkage of the gubernaculum may force the testis through the inguinal canal. endocrine mechanisms that govern testicular descent are not known in detail. The role of the gubernaculum in descent of the testis is controversial. The mechanism of testicular descent has been studied in the rat, because inguino-scrotal descent occurs postnatally in this.

Gubernaculum: Gives rise to: In the inguinal crest a peculiar structure, the gubernaculum testis, makes its appearance. This is at first a slender band, extending from that part of the skin of the groin which afterward forms the scrotum through the inguinal canal to the body and epididymis of the rise to: Scrotal ligament.

To reach the scrotum, the gubernaculum needs several key properties: a mechanism for growing and elongating. a directional signal to ensure migration in the correct direction.

a mechanism for closing the processus vaginalis after testicular descent is by: James Schumacher, in Equine Surgery (Fifth Edition), Gubernaculum. The gubernaculum testis is a fetal, retroperitoneal, mesenchymal cord that extends between the caudal pole of the fetal testis and the scrotum and guides the fetal testis in its descent from the ventral surface of the kidney to its final position in the scrotum (Figure ).

10 The gubernaculum testis of the fetus can be. Contracture of collagen fibres in the gubernaculum has been suggested as a mechanism responsible for fetal descent of the testis. We measured the collagen content of the gubernaculum, fetal thigh muscle and umbilical cord tissue by assaying its hydroxyproline and protein content in male pig fetuses between 60 and days of by: Request PDF | Conclusions and Future Developments | In this chapter we summarise the main conclusions of this book.

Testicular descent has evolved only in. The gubernaculum develops during testicular development as a column of fibrous connective tissue between the inguinal regions to the caudal pole of the testis. The abdominal component of the gubernaculum is covered by mesentery.

The extra-abdominal component is initially attached to the abdominal wall, but moves caudally as the inguinal rings and scrotal sac : Ryan Jennings, Christopher Premanandan. The exact mechanism through which the gubernaculum mediates testicular descent is debated and may involve traction, muscular contraction, or differential growth around a fixed point.

Most likely, the gubernaculum, in conjunction with the processus vaginalis, serves to dilate the inguinal canal and thereby facilitate descent of the testis into the scrotum. The Turkish Journal of Pediatrics ; 46 (supplement): The gubernaculum in testicular descent and cryptorchidism John M.

Hutson1,3, Yasunari Sasaki2, Jenny Huynh1,2, Eric Yong 1,2, Alvin Ting 1FD Stephens Surgical Research Laboratory, 2Murdoch Children Research Institute Department of Pediatrics, University of Melbourne, 3Department of General Surgery, Royal Children's Hospital.

The gubernaculum is present only during the development of the urinary and reproductive organs, being replaced by distinct vestiges in males and females. Males. In males: The upper part of the gubernaculum degenerates.

The lower part persists as the gubernaculum testis ("scrotal ligament"). This ligament secures the testis to the most inferior portion of the scrotum, tethering it in place and limiting the degree to which the testis Gives rise to: Gubernaculum testis (males).

The gubernaculum testis, also called genitoinguinal ligament, connects the testis to the inguinal region and is the key structure for the abdominal part of the descent. A swelling reaction is caused by above mentioned hormones and prevents elongation of the gubernaculum, while the embryo enlarges.The gubernaculum plays an essential role in the complex mechanism of testicular descent [12,13,17,18].

Insulin-like factor 3 (INSL3) appears to play an important role in testicular descent, which involves development of the gubernaculums [ 7, 14, 19 ].Author: Shouxing Duan, Xuewu Jiang, Xuan Zhang, Lei Xie, Zongbo Sun, Shuhua Ma, Jianhong Li.However, the mechanisms by which INSL3 and RXFP2 respective modulate the development of gubernaculum testis cells and how they interact together remain elusive.

The goal of the present study was to evaluate the influence of RXFP2 by its ligand INSL3, and explore the mechanism of testicular descent Author: Shouxing Duan, Xuan Zhang, Xuewu Jiang, Lei Xie, Zongbo Sun, Shuhua Ma, Jianhong Li.